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Aspect:
CC
BP
MF
Multiple Tests:

Type of multiple tests correction to apply.

  • Bonferroni: Reject null hypotheses who P-values are less than the given threshold.
  • BH step-up: Benjamini–Hochberg procedure, controls FDR at given threshold level.
Threshold:
Min Geneset:
Max Geneset:
Similarity Reference:
Year Release
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Enrichment Results

Edition 203 : 2020-12-01 (Total Significant: )

Description:

GO Term Counts by Edition shows counts of unique GO Terms associated with this each enrichment analysis over time.

Legend Descriptions:

All Tested Terms: Count of unique terms that passed all settings criteria.

Significant Terms: Count of unique terms that passed all settings criteria and were significant.

Rejected Terms: Count of unique terms that did not pass all settings criteria.

Controls:

<Click> any edition to view the enrichment results at that point in time in bottom table.

<Click> a legend item to toggle that series.

<Ctrl/Command> + <Click> a legend item to show only that series.

Description:

Enrichment Similarity shows Jaccard similarity of the sets of significantly enriched terms over time.

Legend Descriptions:

The series differ in which sets of terms we are comparing:

All Terms: Compare all significant terms.

Top 5 Terms: Compare the top 5 terms.

Parents of Top Terms: Compare the top 5 terms and all of their ancestors.

Genes Backing Top Terms: Compare the genes that are responsible for the top 5 terms.

Controls:

<Click> any edition to view the term sets described above.

<Click> a legend item to toggle that series.

<Ctrl/Command> + <Click> a legend item to show only that series.

These buttons provide a means to visualize the changes in enrichment results over the history of this hitlist. You may choose from plotting either the top terms in every edition or your selected terms By Rank or By P-Value.

If By Rank is chosen, you will be shown a Bump Chart of the corresponding terms and their relative ranks over time. Areas of heavy change will have lots of crossing lines (and thus appear darker) while areas of stability will have lots of parallel lines (and thus appear lighter and cleaner)

Graph Top Terms Of All Editions:
Graph Selected Terms:

<Click> on to view more details, such as which genes in your hit list are associated with the term.

Gene Ontology ID

<Click> on to view the term's QuickGO entry.

<Click> on to view the term's ancestry chart, NOTE: we do not propagate across aspects whereas QuickGo does.

Metric representing the variability of the term's p-value in its recent past.

This is calculated using six month rolling regressions on the historical changes in 'Pop. Hits' and 'Hits'. Given the results of these regressions we use their 95% confidence intervals to calculate a 95% confidence interval around the p-value. This range is then used to calculate the negative log of the coefficient of variation with respect to that edition's significance cutoff to get the stability score.

The stability score typically ranges between -10 and 10 with 10 being more stable than -10.

A score of No Change means we saw no significant variation in both Pop. Hits and Hits over its recent past (keep in mind this does not mean the p-value is constant).

A score of No Data means there was not enough available.

<Click> on to plot the term's p-value and 95% confidence interval over its history.

Gene Info
Symbol
Accession
Description
Synonyms
Ancestor Chart
buffer
Data Point Information

Plot of the selected term's p-value and 95% confidence interval over its history.

This is calculated using six month rolling regressions on the historical changes in 'Pop. Hits' and 'Hits'. Given the results of these regressions we use their 95% confidence intervals to calculate a 95% confidence interval around the p-value. This range is then used to calculate the negative log of the coefficient of variation with respect to that edition's significance cutoff to get the stability score.

The stability score typically ranges between -10 and 10 with 10 being more stable than -10.

A score of No Change means we saw no significant variation in both Pop. Hits and Hits over its recent past (keep in mind this does not mean the p-value is constant).

A score of No Data means there was not enough available.

Stability
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